Origin of Ribonuclease P RNA ( M 1 RNA )
نویسندگان
چکیده
The origin of RNase P RNA is yet an unsolved problem, although one of us (K.O.) formerly pointed out some sequence similarity between RNase P RNA and virusoids (Ohnishi, 1992). Eigen hypothesized that tRNA is the rst gene from theoretical standpoint. On the other hand, we have postulated polytRNA theory (Ohnishi; Endocytobiology V, 407: 1993; Ann. N.Y. Acad. Sci. 707: 524, 1993; Ohnishi et al.; GIW-93, 325; GIW-96, 238), in which most primitive mRNAs began to evolve from primitive tRNA(s), and at least some mRNAs (e.g., for glycyl tRNA ligase) have evolved from a poly-tRNA ribozyme closely kin to the poly-tRNA region of the B. subtilis trrnD operon transcript. Here we report a possibility that RNase P RNA might have evolved from some tRNA or oligo-tRNA region of the rrnB-type poly-tRNA.
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